IL-32 alpha ELISA Kits

靶标信息

Interleukin 32 alpha (IL-32a) is a distinct isoform of the IL-32 cytokine, initially characterized as a transcript from activated NK cells. The gene encoding IL-32 is structured with eight exons, producing multiple alternatively spliced mRNA isoforms, including IL-32a. This isoform maintains similarity to other IL-32 variants, possessing sites for tyrosine sulfation, N-myristoylation, protein kinase C, casein kinase II phosphorylation, and RGD cell attachment, which are crucial for its functional interactions. IL-32a lacks a transmembrane region and is secreted, implicating a role in inflammation and immune processes by provoking pro-inflammatory cytokines while retaining certain anti-inflammatory features intracellularly. Particularly in the context of immune response, IL-32a is involved in defense mechanisms against intracellular pathogens and may have implications in cancerous processes, given its ability to influence cellular metabolism and proliferation. Its involvement in inflammation and immune regulation underlines its complex role in health and disease.

同义词

IL32; IL-32; IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; interleukin 32; interleukin-32; interleukin-32 eta; interleukin-32 small; interleukin-32 theta; natural killer cell transcript 4; natural killer cells protein 4; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; Tumor necrosis factor alpha-inducing factor